Article
-160C/A polymorphism in the E-cadherin gene promoter and risk of hereditary, familial and sporadic prostate cancer.
International journal of cancer - 10 Apr 2004
Jonsson Björn-Anders, Adami Hans-Olov, Hägglund Maria, Bergh Anders, Göransson Ingela, Stattin Pär, Wiklund Fredrik, Grönberg Henrik
Abstract excerpt
The E-cadherin (CDH1) gene has been associated with prostate carcinogenesis. The C/A polymorphism--160 base pairs relative to the transcription start site has been shown to decrease gene transcription. We analyzed the association between this polymorphism and the risk of sporadic, familial (2 close relatives) and hereditary (3 or more close relatives) prostate cancer. We combined data from 3 population-based...
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