Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer.

Cancer research - 15 Mar 2004

Chang Bao-li, Zheng Siqun L, Isaacs Sarah D, Wiley Kathy E, Turner Aubrey, Li Ge, Walsh Patrick C, Meyers Deborah A, Isaacs William B, Xu Jianfeng

Abstract excerpt

The loss of cell cycle control is believed to be an important mechanism in the promotion of carcinogenesis. CDKN1B (p27) belongs to the Cip/Kip family and functions as an important cell cycle gatekeeper. Several lines of evidence from clinical studies and laboratory experiments demonstrate that CDKN1B is an important tumor suppressor gene in prostate cancer etiology. In addition, a case-control study has shown...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Family Health

Share to Germ-Line Mutation

Share to Prostatic Neoplasms

Share to Risk Factors

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 15026335
DOI: 10.1158/0008-5472.can-03-2340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer.PMID 15026335Read ↗

CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma.Semantic proximity Read ↗

Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human TumorsSemantic proximity Read ↗

Population-Based Estimate of Prostate Cancer Risk for Carriers of the HOXB13 Missense Mutation G84ESemantic proximity Read ↗

Clinical Significance of Gene Mutations and Polymorphic Variants and their Association with Prostate Cancer Risk in Polish Men.Semantic proximity Read ↗

Germline Mutations in HOXB13 and Prostate-Cancer RiskSemantic proximity Read ↗

Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer.Semantic proximity Read ↗

Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women.Semantic proximity Read ↗

Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer.Semantic proximity Read ↗

The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma.Semantic proximity Read ↗

NBS1 is a prostate cancer susceptibility gene.Semantic proximity Read ↗

A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype.Semantic proximity Read ↗

The HOXB13 p.Gly84Glu variant observed in an extended five generation high-risk prostate cancer pedigree supports risk association for multiple cancer sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.