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Article

RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.

Oncogene - 25 Oct 2001

Barone M V, Sepe L, Melillo R M, Mineo A, Santelli G, Monaco C, Castellone M D, Tramontano D, Fusco A, Santoro M

Abstract excerpt

Thyroid papillary carcinomas are characterized by RET/PTC rearrangements that cause the tyrosine kinase domain of the RET receptor to fuse with N-terminal sequences encoded by heterologous genes. This results in the aberrant expression of a ligand-independent and constitutively active RET kinase. We analysed actin reorganization induced by the RET/PTC1 oncogene in PC Cl 3 rat thyroid epithelial cells. Differently...

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Share to 3T3 Cells
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Endocrine Neoplasia Type 2a

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Proteins c-ret

Share to rho GTP-Binding Proteins

Share to Stress Fibers

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Source

Identifiers

PMID: 11704822
DOI: 10.1038/sj.onc.1204886

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.PMID 11704822Read ↗

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