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Article

Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.

Oncogene - 16 Jan 2003

Castellone Maria Domenica, Cirafici Anna Maria, De Vita Gabriella, De Falco Valentina, Malorni Luca, Tallini Giovanni, Fagin James A, Fusco Alfredo, Melillo Rosa Marina, Santoro Massimo

Abstract excerpt

RET gene rearrangements, which generate chimeric RET/PTC oncogenes, are early events in the evolution of thyroid papillary carcinomas. Expression of RET/PTC oncogenes promotes neoplastic transformation of cultured thyroid cells and of thyroid glands in transgenic mice. Notwithstanding these oncogenic effects, we have found that the expression of two RET/PTC oncogenes (H4-RET and RFG-RET) induces apoptosis of rat...

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PMID: 12527893
DOI: 10.1038/sj.onc.1206112

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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