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Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers.

Endocrinology - 1 Oct 2008

Burniat Agnès, Jin Ling, Detours Vincent, Driessens Natacha, Goffard Jean-Christophe, Santoro Massimo, Rothstein Jay, Dumont Jacques E, Miot Françoise, Corvilain Bernard

Abstract excerpt

We studied gene expression profiles in two mouse models of human thyroid carcinoma: the Tg-RET/PTC3 (RP3) and Tg-E7 mice. RP3 fusion gene is the most frequent mutation found in the first wave post-Chernobyl papillary thyroid cancers (PTCs). E7 is an oncoprotein derived from the human papillomavirus 16 responsible for most cervical carcinoma in women. Both transgenic mice develop thyroid hyperplasia followed by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Viral

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Identifiers

PMID: 18583418
DOI: 10.1210/en.2008-0531

Genes

RET
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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