Article
Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses.
Genes and immunity - 1 Nov 2001
Roper R J, Weis J J, McCracken B A, Green C B, Ma Y, Weber K S, Fairbairn D, Butterfield R J, Potter M R, Zachary J F, Doerge R W, Teuscher C
Abstract excerpt
C3H/He mice infected with Borrelia burgdorferi develop severe arthritis and are high antibody responders, while infected C57BL/6 and BALB/c mice develop mild arthritis and less robust humoral responses. Genetic analysis using composite interval mapping (CIM) on reciprocal backcross populations derived from C3H/HeN and C57BL/6N or C3H/HeJ and BALB/cAnN mice identified 12 new quantitative trait loci (QTL) linked to...
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