Article
Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes.
Arthritis research & therapy - 1 Jan 2009
Lindvall Therese, Karlsson Jenny, Holmdahl Rikard, Andersson Asa
Abstract excerpt
INTRODUCTION: In a cross between two mouse strains, the susceptible B10.RIII (H-2(r)) and resistant RIIIS/J (H-2(r)) strains, a locus on mouse chromosome 5 (Eae39) was previously shown to control experimental autoimmune encephalomyelitis (EAE). Recently, quantitative trait loci (QTL), linked to disease indifferent experimental arthritis models, were mapped to this region. The aim of the present study was to...
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