Article
Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim).
Bone - 1 Nov 2001
Grabner B, Landis W J, Roschger P, Rinnerthaler S, Peterlik H, Klaushofer K, Fratzl P
Abstract excerpt
Cortical mineralization of long bones was studied in collagen alpha2(I)-deficient mice (oim) used as a model for human osteogenesis imperfecta. Aspects of the age development of the mice were characterized by combining nanometer- to micrometer-scale structural analysis with microhardness measurements. Bone structure was determined from homozygous (oim/oim) and heterozygous (oim/+) mice and their normal (+/+)...
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