Characterization of the osteochondral phenotype in human classical osteogenesis imperfecta and in Col1a2oim/oim mice.

Abstract excerpt

Osteogenesis imperfecta (OI) is associated with an increased risk of early-onset osteoarthritis (OA); however, it remains unclear whether this risk is driven by underlying osteochondral alterations. Here, we aimed to characterize the osteochondral phenotype in OI to identify osteochondral features that may be relevant to increased OA susceptibility. We collected bilateral tibial plateaus from one adult with...

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