Article

Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice

2020-07-14

Abstract excerpt

Type I collagen is the major structural component of bone where it exists as an (α1) 2 (α2) 1 heterotrimer in all vertebrates. The osteogenesis imperfecta (oim) mouse model comprising solely homotrimeric (α1) 3 type I collagen, due to a dysfunctional α2 chain, has a brittle bone phenotype implying that the heterotrimeric form is required for physiological bone function. However, humans with rare null alleles pr...

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Literature Corpus work: 42f25f95-c000-5f92-a077-c322e4462c66
DOI: 10.1101/2020.07.13.198283

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