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Article

Role of genetic background in determining phenotypic severity throughout postnatal development and at peak bone mass in Col1a2 deficient mice (oim).

Bone - 1 Apr 2008

Carleton Stephanie M, McBride Daniel J, Carson William L, Huntington Carolyn E, Twenter Kristin L, Rolwes Kristin M, Winkelmann Christopher T, Morris J Steve, Taylor Jeremy F, Phillips Charlotte L

Abstract excerpt

Osteogenesis imperfecta (OI) is a genetically and clinically heterogeneous disease characterized by extreme bone fragility. Although fracture numbers tend to decrease post-puberty, OI patients can exhibit significant variation in clinical outcome, even among related individuals harboring the same mutation. OI most frequently results from mutations in type I collagen genes, yet how genetic background impacts...

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Identifiers

PMID: 18313376
DOI: 10.1016/j.bone.2007.12.215
PMCID: PMC2423326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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