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Article

Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density.

Bone - 1 Aug 2000

Phillips C L, Bradley D A, Schlotzhauer C L, Bergfeld M, Libreros-Minotta C, Gawenis L R, Morris J S, Clarke L L, Hillman L S

Abstract excerpt

To investigate the role of the pro alpha 2(I) collagen chains of type I collagen in mineralization we used the oim (osteogenesis imperfecta model) mouse as our model system. The oim/oim mouse (homozygous for a null mutation in its COL1A2 gene of type I collagen) fails to synthesize functional pro alpha 2(I) collagen chains, synthesizing only homotrimers of pro alpha 1(I) collagen chains. To evaluate the role of...

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Identifiers

PMID: 10913914
DOI: 10.1016/s8756-3282(00)00311-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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