Article
Bone geometry and strength measurements in aging mice with the oim mutation.
Calcified tissue international - 1 Feb 1998
McBride D J, Shapiro J R, Dunn M G
Abstract excerpt
Mice with the naturally occurring oim mutation allows investigation of bone pathobiology in the setting of one mutation: a G deletion in the murine Cola-2 gene (exon 52) encoding the proalpha2(I) C-propeptide. As a result, normal sized mRNA is transcribed, but no secreted protein has been identified in oim/oim fibroblasts or osteoblasts. Here we report longitudinal changes in body mass, bone geometry, and bone...
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