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Article

Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication.

Nucleic acids research - 1 Jan 2006

Johnson Rory, Gamblin Richard J, Ooi Lezanne, Bruce Alexander W, Donaldson Ian J, Westhead David R, Wood Ian C, Jackson Richard M, Buckley Noel J

Abstract excerpt

The genome-wide mapping of gene-regulatory motifs remains a major goal that will facilitate the modelling of gene-regulatory networks and their evolution. The repressor element 1 is a long, conserved transcription factor-binding site which recruits the transcriptional repressor REST to numerous neuron-specific target genes. REST plays important roles in multiple biological processes and disease states. To map RE1...

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Identifiers

PMID: 16899447
DOI: 10.1093/nar/gkl525
PMCID: PMC1557810

Genes

REST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication.PMID 16899447Read ↗

Genome-wide assessment of REST binding profiles reveals distinctions between human and mouse hippocampusSemantic proximity Read ↗

Whole genome functional characterization of RE1 silencers using a modified massively parallel reporter assaySemantic proximity Read ↗

A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes.Semantic proximity Read ↗

Comprehensive analysis of the REST transcription factor regulatory networks in IDH mutant and IDH wild-type glioma cell lines and tumors.Semantic proximity Read ↗

Expert Curation of the Human and Mouse Olfactory Receptor Gene Repertoires Identifies Conserved Coding Regions Split Across Two ExonsSemantic proximity Read ↗

Biological activity of RE-1 silencing transcription factor (REST) towards distinct transcriptional activators.Semantic proximity Read ↗

Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions.Semantic proximity Read ↗

Mutations in the transcriptional repressor REST predispose to Wilms tumor.Semantic proximity Read ↗

Expert Curation of the Human and Mouse Olfactory Receptor Gene Repertoires Identifies Conserved Coding Regions Split Across Two Exons.Semantic proximity Read ↗

SIRT6-dependent functional switch via K494 modifications of RE-1 Silencing Transcription factorSemantic proximity Read ↗

Spatiotemporal expression of Rest in the brain of Ts1Cje mouse model of Down syndromeSemantic proximity Read ↗

Identification and characterization of repressive domains in <i>Drosophila</i> transcription factorsSemantic proximity Read ↗

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