Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.

doi:10.1091/mbc.4.9.919

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Article

Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.

Molecular biology of the cell - 1 Sept 1993

Kurihara T, Silver P

Abstract excerpt

Mutations in the SEC63 gene are associated with defects in protein translocation into the endoplasmic reticulum (ER) as well as in nuclear protein localization in Saccharomyces cerevisiae. To identify proteins that might interact and/or function with SEC63p, we cloned a high copy suppressor (HSS1) of the temperature-sensitive lethal phenotype of the sec63-101 mutant. HSS1 is an allele-specific sec63 suppressor...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosomes, Fungal
Cloning, Molecular
DNA Primers
Endoplasmic Reticulum
Fungal Proteins
Genes, Fungal
Genes, Lethal
Glycoside Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HSP70 Heat-Shock Proteins

Heat-Shock Proteins

Membrane Glycoproteins

Membrane Proteins

Membrane Transport Proteins

Molecular Sequence Data

Mutagenesis, Site-Directed

Source

Open in PubMed Open full text

Identifiers

PMID: 8257794
DOI: 10.1091/mbc.4.9.919
PMCID: PMC275722

Genes

SEC63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8257794-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.PMID 8257794Read ↗

Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Ssh1p determines the translocation and dislocation capacities of the yeast endoplasmic reticulum.Semantic proximity Read ↗

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