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Article

Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain.

Journal of molecular biology - 9 Nov 2001

Davis D P, Gallo G, Vogen S M, Dul J L, Sciarretta K L, Kumar A, Raffen R, Stevens F J, Argon Y

Abstract excerpt

Deposition of monoclonal immunoglobulin light chain (LC) aggregates in tissues is the hallmark of a class of fatal diseases with no effective treatment. In the most prevalent diseases two different types of LC aggregates are observed: fibrillar deposits in LC amyloidosis (AL) and granular aggregates in LC deposition disease (LCDD). The mechanisms by which a given LC forms either type of aggregate are not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11700059
DOI: 10.1006/jmbi.2001.5092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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