Article

Extracellular chaperones modulate AL light chains fibrillar aggregation and contribute to amyloid structural heterogeneity

2026-06-02

Abstract excerpt

<h4>ABSTRACT</h4> In AL amyloidosis, monoclonal immunoglobulin light chains (LCs) aggregate as amyloid fibrils in tissues. In synergy with the intrinsic aggregation propensity of specific LC sequences, microenvironment factors may be involved in tuning the disease pathophysiology, in particular proteolytic LC remodelling and heterotypic interactions in the extracellular milieu. Accounting for extrinsic modulators...

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Literature Corpus work: 7cc721c3-6b3c-52d0-a312-bd7e5122270f
DOI: 10.64898/2026.05.29.728721

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