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Article

Immunoglobulin light chain amyloid aggregation.

Chemical communications (Cambridge, England) - 20 Sept 2018

Blancas-Mejia Luis M, Misra Pinaki, Dick Christopher J, Cooper Shawna A, Redhage Keely R, Bergman Michael R, Jordan Torri L, Maar Khansaa, Ramirez-Alvarado Marina

Abstract excerpt

Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding disease. It is characterized by an abnormal proliferation of plasma cells (fully differentiated B cells) producing an excess of monoclonal immunoglobulin light chains that are secreted into circulation, where the light chains misfold, aggregate as amyloid fibrils in target organs, and cause organ dysfunction, organ failure,...

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Share to Amyloid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glycosaminoglycans

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Source

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Identifiers

PMID: 30087961
DOI: 10.1039/c8cc04396e
PMCID: PMC6148388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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