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Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains

25 Jun 2019

Abstract excerpt

Little is known about the mechanism of amyloid assembly in immunoglobulin light chain (AL) amyloidosis, in contrast to other amyloid diseases. Early events in the aggregation pathway are especially important, as these soluble species could be cytotoxic intermediates playing a critical role in the initiation of the amyloid assembly. In this work, we discuss the mechanism of the early events in in vitro fibril...

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PMID: 31287666
DOI: 10.1021/acs.biochem.9b00311

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