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Article

A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis.

Communications biology - 23 Feb 2023

Rottenaicher Georg J, Absmeier Ramona M, Meier Laura, Zacharias Martin, Buchner Johannes

Abstract excerpt

Light chain (AL) amyloidosis is a debilitating disease in which mutant antibody light chains (LC), secreted by aberrant plasma cell clones, misfold and form insoluble fibrils, which can be deposited in various organs. In the majority of cases, the fibrillar deposits consist of LC variable domains (VL) containing destabilizing mutations compared to their germline counterparts. This is also true for the patient LC...

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Identifiers

PMID: 36823438
DOI: 10.1038/s42003-023-04574-y
PMCID: PMC9950467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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