Article
Light chain amyloidosis - current findings and future prospects.
Current protein & peptide science - 1 Oct 2009
Baden Elizabeth M, Sikkink Laura A, Ramirez-Alvarado Marina
Abstract excerpt
Systemic light chain amyloidosis (AL) is one of several protein misfolding diseases and is characterized by extracellular deposition of immunoglobulin light chains in the form of amyloid fibrils [1]. Immunoglobulin (Ig) proteins consist of two light chains (LCs) and two heavy chains (HCs) that ordinarily form a heterotetramer which is secreted by a plasma cell. In AL, however, a monoclonal plasma cell population...
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