Article

Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway

2024-12-05

Abstract excerpt

<h4>ABSTRACT</h4> Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by the misfolding and aggregation of free immunoglobulin light chains (LCs) secreted by abnormal plasma cells. The resulting amyloid fibrils deposit in multiple organs, leading to progressive dysfunction and increased morbidity and mortality. Despite recent advances, the molecular determinants of LC aggregation and phenoty...

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Literature Corpus work: d450d2e3-91da-5d72-bca2-77d374518a9e
DOI: 10.1101/2024.12.04.626857

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