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Article

Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosis.

The Journal of biological chemistry - 31 Dec 2010

Hwang Young-Mi, Stathopulos Peter B, Dimmick Kristin, Yang Hong, Badiei Hamid R, Tong Ming Sze, Rumfeldt Jessica A O, Chen Pu, Karanassios Vassili, Meiering Elizabeth M

Abstract excerpt

Protein aggregation is a hallmark of many diseases, including amyotrophic lateral sclerosis (ALS) where aggregation of copper/zinc superoxide dismutase (SOD1) is implicated in pathogenesis. We report here that fully metallated (holo) SOD1 under physiologically relevant solution conditions can undergo changes in metallation and/or dimerization over time and form aggregates that do not exhibit classical...

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Identifiers

PMID: 20974846
DOI: 10.1074/jbc.M110.113696
PMCID: PMC3009897

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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