Article
Amyloid formation in light chain amyloidosis.
Current topics in medicinal chemistry - 1 Jan 2012
Ramirez-Alvarado Marina
Abstract excerpt
Light chain amyloidosis is one of the unique examples within amyloid diseases where the amyloidogenic precursor is a protein that escapes the quality control machinery and is secreted from the cells to be circulated in the bloodstream. The immunoglobulin light chains are produced by an abnormally proliferative monoclonal population of plasma cells that under normal conditions produce immunoglobulin molecules such...
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