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Article

A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2001

Lou Z, Billadeau D D, Savoy D N, Schoon R A, Leibson P J

Abstract excerpt

Polarization of lipid rafts and granules to the site of target contact is required for the development of cell-mediated killing by cytotoxic lymphocytes. We have previously shown that these events require the activation of proximal protein tyrosine kinases. However, the downstream intracellular s...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11698448
DOI: 10.4049/jimmunol.167.10.5749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11698448-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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