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Article

Lymphocyte-Mediated Cytotoxicity

1 Apr 2002

Abstract excerpt

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the Fas pathway. The granule exocytosis pathway utilizes perforin to traffic the granzymes to appropriate locations in target cells, where they cleave critical substrates that initiate DNA fragmentation and apoptosis; granzymes A and B induce...

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Identifiers

PMID: 11861606
DOI: 10.1146/annurev.immunol.20.100201.131730

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