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Article

Assessment of lymphocyte-mediated cytotoxicity using flow cytometry.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004

Liu Luzheng, Packard Beverly Z, Brown Martin J, Komoriya Akira, Feinberg Mark B

Abstract excerpt

Cytotoxic lymphocytes, including cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, kill target cells by releasing granules containing perforin and granzymes, and/or via Fas-Fas ligand interactions. Both pathways lead to prompt activation within target cells of caspase cascades responsible for apoptosis induction and cell death. We have utilized cell-permeable fluorogenic caspase substrates and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14976364
DOI: 10.1385/1-59259-773-4:125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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