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Article

Resistance of tumor cells to cytolytic T lymphocytes involves Rho-GTPases and focal adhesion kinase activation.

The Journal of biological chemistry - 14 Nov 2008

Abouzahr-Rifai Soraya, Hasmim Meriem, Boukerche Habib, Hamelin Jocelyne, Janji Bassam, Jalil Abdelali, Kieda Claudine, Mami-Chouaib Fathia, Bertoglio Jacques, Chouaib Salem

Abstract excerpt

Tumor cells evade adaptive immunity by a variety of mechanisms, including selection of variants that are resistant to specific cytotoxic T lymphocyte (CTL) pressure. Recently, we have reported that the reorganization of the actin cytoskeleton can be used by tumor cells as a strategy to promote their resistance to CTL-mediated lysis. In this study, we further examined the functional features of a CTL-resistant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18779334
DOI: 10.1074/jbc.M800078200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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