Article
A role for Rab7 in the movement of secretory granules in cytotoxic T lymphocytes.
Traffic (Copenhagen, Denmark) - 1 Jul 2011
Daniele Tiziana, Hackmann Yvonne, Ritter Alex T, Wenham Matt, Booth Sarah, Bossi Giovanna, Schintler Michael, Auer-Grumbach Michaela, Griffiths Gillian M
Abstract excerpt
Cytotoxic T lymphocytes (CTL) are potent killers of virally infected and tumorigenic cells. Upon recognition of target cells, CTL undergo polarized secretion of secretory lysosomes at the immunological synapse (IS) that forms between CTL and target. However, the molecular machinery involved in the polarization of secretory lysosomes is still largely uncharacterized. In this paper, we investigated the role of Rab7...
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