Article
The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing.
The Journal of cell biology - 12 Jun 2000
Sancho D, Nieto M, Llano M, Rodríguez-Fernández J L, Tejedor R, Avraham S, Cabañas C, López-Botet M, Sánchez-Madrid F
Abstract excerpt
The compartmentalization of plasma membrane proteins has a key role in regulation of lymphocyte activation and development of immunity. We found that the proline-rich tyrosine kinase-2 (PYK-2/RAFTK) colocalized with the microtubule-organizing center (MTOC) at the trailing edge of migrating natural killer (NK) cells. When polyclonal NK cells bound to K562 targets, PYK-2 translocated to the area of NK-target cell...
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