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Article

Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.

Journal of molecular biology - 2 Nov 2001

Liu W L, Midgley C, Stephen C, Saville M, Lane D P

Abstract excerpt

The p53 tumour suppressor protein plays a central role in maintaining genomic integrity in eukaryotic cells. The most significant biological function of p53 is to act as a sequence-specific DNA-binding transcription factor, which can induce the expression of a variety of target genes in response to diverse stress stimuli. The p53 protein contains six highly conserved regions, one of which, termed Box I, is...

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Identifiers

PMID: 11697899
DOI: 10.1006/jmbi.2001.5082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.PMID 11697899Read ↗

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p53 Amino-terminus region (1-125) stabilizes and restores heat denatured p53 wild phenotype.Semantic proximity Read ↗

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