The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

doi:10.1101/gad.7.12b.2556

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Article

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

Genes & development - 1 Dec 1993

Pavletich N P, Chambers K A, Pabo C O

Abstract excerpt

Mutations in the p53 tumor suppressor gene are the most commonly observed genetic alterations in human cancer. The majority of these mutations occur in the conserved central portion of the gene, but there has been little information about the function of this region. Using proteolytic digestion o...

Topics

Amino Acid Sequence
Base Sequence
Binding Sites
Conserved Sequence
DNA
Humans
Molecular Sequence Data
Mutation
Tumor Suppressor Protein p53
Zinc

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