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Article

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

Genes & development - 1 Dec 1993

Pavletich N P, Chambers K A, Pabo C O

Abstract excerpt

Mutations in the p53 tumor suppressor gene are the most commonly observed genetic alterations in human cancer. The majority of these mutations occur in the conserved central portion of the gene, but there has been little information about the function of this region. Using proteolytic digestion of the 393-amino-acid human p53 protein, we have identified a 191-amino-acid protease-resistant fragment (residues...

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PMID: 8276238
DOI: 10.1101/gad.7.12b.2556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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