Article

Mutational Hotspots and Conserved Domains in P53 Tumour Suppressor Protein

2020-08-26

Abstract excerpt

<h4>Introduction: </h4> The tumour suppressor protein p53 commonly referred to as guardian of the genome plays important role in preserving the genome through the regulation of programmed cell death, DNA repair, energy metabolism, cell cycle entry or exit and senescence. Mutations in p53 can either result to a loss of tumour suppressor function or gain of oncogenic properties. Hence, mutations in p53 are the most...

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Literature Corpus work: 6614170e-7313-5d7f-91e7-7f9185ec9352
DOI: 10.20944/preprints202008.0562.v1

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