Article
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.
Science (New York, N.Y.) - 15 Jul 1994
Cho Y, Gorina S, Jeffrey P D, Pavletich N P
Abstract excerpt
Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations in human cancer. The majority of the mutations occur in the core domain which contains the sequence-specific DNA binding activity of the p53 protein (residues 102-292), and they result in loss of DNA bindin...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Computer Graphics
- Crystallization
- Crystallography, X-Ray
- DNA
- Genes, p53
- Hydrogen Bonding
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Conformation
- Protein Structure, Secondary
- Tumor Suppressor Protein p53