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Article

Cytochrome P450 reaction-phenotyping: an industrial perspective.

Expert opinion on drug metabolism & toxicology - 1 Oct 2007

Zhang Hongjian, Davis Carl D, Sinz Michael W, Rodrigues A David

Abstract excerpt

It is now widely accepted that the fraction of the dose metabolized by a given drug-metabolizing enzyme is one of the major factors governing the magnitude of a drug interaction and the impact of a polymorphism on (total) drug clearance. Therefore, most pharmaceutical companies determine the enzymes involved in the metabolism of a new chemical entity (NCE) in vitro, in conjunction with human data on absorption,...

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Identifiers

PMID: 17916054
DOI: 10.1517/17425255.3.5.667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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