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Article

Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease.

Pharmacogenetics - 1 Nov 2001

Farin F M, Janssen P, Quigley S, Abbott D, Hassett C, Smith-Weller T, Franklin G M, Swanson P D, Longstreth W T, Omiecinski C J, Checkoway H

Abstract excerpt

Oxidative stress is hypothesized to play a major role in the destruction of dopaminergic neurons, which is associated with Parkinson's disease. Epoxides are potentially reactive intermediates formed through the oxidative metabolism of both exogenous and endogenous substances that contribute to cytotoxic damage mediated by oxidative stress. The microsomal (EPHX1) and soluble (EPHX2) epoxide hydrolases function to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11692079
DOI: 10.1097/00008571-200111000-00009

Genes

EPHX1
EPHX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease.PMID 11692079Read ↗

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The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter.Semantic proximity Read ↗

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