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Article

The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter.

The Journal of pharmacology and experimental therapeutics - 1 Jul 2009

Yang Xi, Liang Shun-Hsin, Weyant Denise M, Lazarus Philip, Gallagher Carla J, Omiecinski Curtis J

Abstract excerpt

Microsomal epoxide hydrolase (EPHX1) biotransforms epoxide derivatives of pharmaceuticals, including metabolites of certain antiepileptic medications, such as phenytoin and carbamazepine, and many environmental epoxides, such as those derived from butadiene, benzene, and carcinogenic polyaromatic hydrocarbons. We previously identified a far upstream promoter region, designated E1-b, in the EPHX1 gene that directs...

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Source

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Identifiers

PMID: 19364907
DOI: 10.1124/jpet.109.150870
PMCID: PMC2700158

Genes

EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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