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Article

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease.

Gene - 15 Oct 2015

Václavíková Radka, Hughes David J, Souček Pavel

Abstract excerpt

Microsomal epoxide hydrolase (EPHX1) is an evolutionarily highly conserved biotransformation enzyme for converting epoxides to diols. Notably, the enzyme is able to either detoxify or bioactivate a wide range of substrates. Mutations and polymorphic variants in the EPHX1 gene have been associated with susceptibility to several human diseases including cancer. This review summarizes the key knowledge concerning...

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Share to Epoxide Hydrolases
Share to Gene Expression Regulation, Enzymologic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Liver Diseases, Alcoholic

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 26216302
DOI: 10.1016/j.gene.2015.07.071
PMCID: PMC4544754

Genes

EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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