Article
The role of hPMS1 and hPMS2 in predisposing to colorectal cancer.
Cancer research - 1 Nov 2001
Liu T, Yan H, Kuismanen S, Percesepe A, Bisgaard M L, Pedroni M, Benatti P, Kinzler K W, Vogelstein B, Ponz de Leon M, Peltomäki P, Lindblom A
Abstract excerpt
Hereditary nonpolyposis colorectal cancer (HNPCC) is attributable to a deficiency of mismatch repair. Inactivation of DNA mismatch repair underlies the genesis of microsatellite instability in colorectal cancer. Germline mutations in three DNA mismatch repair genes, hMSH2, hMLH1, and hMSH6, have been found to segregate in HNPCC and HNPCC-like families. The two DNA mismatch repair genes hPMS1 and hPMS2 have also...
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