Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations.

Clinical genetics - 1 Mar 2004

Thompson E, Meldrum C J, Crooks R, McPhillips M, Thomas L, Spigelman A D, Scott R J

Abstract excerpt

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant, inherited condition that is characterized primarily by the development of early-onset colorectal cancer and a number of other epithelial malignancies. The underlying genetic basis of the disease is associated with a breakdown of DNA-mismatch repair. There are many genes involved in DNA-mismatch repair, and five of them have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to DNA Repair Enzymes

Share to Exodeoxyribonucleases

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Source

Identifiers

PMID: 14756672
DOI: 10.1111/j.1399-0004.2004.00214.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations.PMID 14756672Read ↗

Is hEXO1 a Cancer Predisposing Gene?Semantic proximity Read ↗

The role of hPMS1 and hPMS2 in predisposing to colorectal cancer.Semantic proximity Read ↗

HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes.Semantic proximity Read ↗

Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome.Semantic proximity Read ↗

hMLH1 mutations in hereditary nonpolyposis colorectal cancer kindreds. Mutations in brief no. 182. Online.Semantic proximity Read ↗

Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 Eastern United States hereditary nonpolyposis colorectal cancer pedigrees.Semantic proximity Read ↗

After hMSH2 and hMLH1--what next? Analysis of three-generational, population-based, early-onset colorectal cancer families.Semantic proximity Read ↗

Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds.Semantic proximity Read ↗

Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review.Semantic proximity Read ↗

Molecular genetics of hereditary non-polyposis colorectal cancer (HNPCC).Semantic proximity Read ↗

Gene symbol: hMLH1. Disease: Hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

HMLH1 and HMSH2 germline mutations in Greek families with hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.