Molecular genetics of hereditary non-polyposis colorectal cancer (HNPCC).

doi:10.1177/030089169608200206

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Article

Molecular genetics of hereditary non-polyposis colorectal cancer (HNPCC).

Tumori - 1 Jan 2000

Cama A, Genuardi M, Guanti G, Radice P, Varesco L

Abstract excerpt

The story of the molecular genetics of HNPCC is one of astonishingly rapid achievements. In just 16 months, from May 1993 to September 1994, four different genes, namely hMSH2, hMLH1, hPMS1 and hPMS2 have been identified and demonstrated to be associated with the disease. Their cloning was facili...

Topics

Colorectal Neoplasms, Hereditary Nonpolyposis
DNA, Neoplasm
Germ-Line Mutation
Heterozygote
Humans
Microsatellite Repeats
Mutation

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