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Article

On the origin of p53 G:C --> T:A transversions in lung cancers.

Mutation research - 31 Oct 2002

Rodin Sergei N, Rodin Andrew S

Abstract excerpt

The high frequency of G-->T transversions in the p53 gene is a distinctive feature of lung cancer patients with a smoking history and is commonly believed to reflect the direct mutagenic signature of polycyclic aromatic hydrocarbon (PAH) adducts along the gene. Using the April 2000 update of the p53 mutation database of the International Agency for Research on Cancer together with the primary literature, we...

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Identifiers

PMID: 12379456
DOI: 10.1016/s0027-5107(02)00106-9

Genes

PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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