Article
Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis.
BMC molecular biology - 20 Jun 2007
Takahasi K Ryo, Sakuraba Yoshiyuki, Gondo Yoichi
Abstract excerpt
BACKGROUND: With the advent of sequence-based approaches in the mutagenesis studies, it is now possible to directly evaluate the genome-wide pattern of experimentally induced DNA sequence changes for a diverse array of organisms. To gain a more comprehensive understanding of the mutational bias inherent in mouse ENU mutagenesis, this study describes a detailed evaluation of the induced mutational pattern obtained...
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