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Origins of spontaneous mutations: specificity and directionality of base-substitution, frameshift, and sequence-substitution mutageneses.

Annual review of genetics - 1 Jan 2002

Maki Hisaji

Abstract excerpt

Spontaneous mutations are derived from various sources, including errors made during replication of undamaged template DNA, mutagenic nucleotide substrates, and endogenous DNA lesions. These sources vary in their frequencies and resultant mutations, and are differently affected by the DNA sequence, DNA transactions, and cellular metabolism. Organisms possess a variety of cellular functions to suppress spontaneous...

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PMID: 12429694
DOI: 10.1146/annurev.genet.36.042602.094806

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