Article
CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2001
Murphy G M, Pollock B G, Kirshner M A, Pascoe N, Cheuk W, Mulsant B H, Reynolds C F
Abstract excerpt
Recent advances in oligonucleotide microarray technology ("gene chips") permit rapid screening for DNA sequence variation. The CYP2D6 gene encodes debrisoquine hydroxylase, which metabolizes the antidepressant nortriptyline and other psychotropic medications. Nortriptyline plasma concentrations were obtained after at least three weeks of treatment in 36 geriatric patients with major depression who were taking a...
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