Nonlinear kinetics of nortriptyline in relation to nortriptyline clearance as observed during therapeutic drug monitoring.

doi:10.1007/BF00195918

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Article

Nonlinear kinetics of nortriptyline in relation to nortriptyline clearance as observed during therapeutic drug monitoring.

European journal of clinical pharmacology - 1 Jan 1994

Jerling M, Alván G

Abstract excerpt

From routine therapeutic drug monitoring data, samples from 105 patients with two analyses of nortriptyline at different daily doses were collected. The ratio between concentration and daily dose, which is the reciprocal of the apparent clearance, was compared intra-individually to study the occu...

Topics

Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
Drug Monitoring
Humans
Mixed Function Oxygenases
Nortriptyline
Phenotype
Regression Analysis

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