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Article

Pharmacogenetics of desipramine metabolism.

International journal of clinical pharmacology and therapeutics - 1 Mar 1994

Musa M N, Miescke K J

Abstract excerpt

There is wide interindividual variation in steady-state plasma concentration of desipramine and other tricyclic antidepressants primarily due to differences in rates of hydroxylation. Several studies have shown that the rate of hydroxylation of desipramine is correlated with the rate of hydroxylation of the genetic probe drug, debrisoquine, which is controlled by monogenic inheritance. However, no population...

Topics

Adolescent
Adult
Antidepressive Agents, Tricyclic
Chromatography, High Pressure Liquid
Depressive Disorder
Desipramine
Energy Metabolism
Female
Genotype
Humans
Male
Mathematics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Pharmacogenetics

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Identifiers

PMID: 8205373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8205373-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Pharmacogenetics of desipramine metabolism.PMID 8205373Read ↗

Polymorphic 2-hydroxylation of desipramine. A population and family study.Semantic proximity Read ↗

Impact of CYP2D6 intermediate metabolizer alleles on single-dose desipramine pharmacokinetics.Semantic proximity Read ↗

Metabolism of desipramine in Japanese psychiatric patients: the impact of CYP2D6 genotype on the hydroxylation of desipramine.Semantic proximity Read ↗

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population.Semantic proximity Read ↗

Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug-drug interaction trials.Semantic proximity Read ↗

Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogenetics.Semantic proximity Read ↗

Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients.Semantic proximity Read ↗

Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group.Semantic proximity Read ↗

Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study.Semantic proximity Read ↗

Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study.Semantic proximity Read ↗

The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults.Semantic proximity Read ↗

Phenobarbital induces the 2-hydroxylation of desipramine.Semantic proximity Read ↗

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