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Article

Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity.

Journal of medical toxicology : official journal of the American College of Medical Toxicology - 1 Sept 2011

Smith Jennifer Cohen, Curry Steven C

Abstract excerpt

INTRODUCTION: Amitriptyline and its metabolite, nortriptyline, are metabolized, in part, by CYP2D6, a polymorphic enzyme. About 8% of Caucasians are deficient in CYP2D6 activity. CASE REPORT: We present the case of a comatose woman who intentionally overdosed on amitriptyline and displayed rising serum total tricyclic antidepressant concentrations for at least 6 days after admission. Serial immunoassay total...

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Identifiers

PMID: 21614669
DOI: 10.1007/s13181-011-0158-2
PMCID: PMC3550197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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