Article
Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia.
Psychopharmacology bulletin - 1 Jan 1995
Pollock B G, Mulsant B H, Sweet R A, Rosen J, Altieri L P, Perel J M
Abstract excerpt
Older patients have more adverse experiences when treated with psychotropics than younger patients. Age-associated physiological changes, such as reductions in hepatic mass and blood flow, magnify genetic and acquired variations in drug metabolism. Cytochrome P450 2D6 (debrisoquine hydroxylase), which is responsible for the metabolism of several antidepressants and neuroleptics, is constitutionally deficient in...
Topics
- Aged
- Alzheimer Disease
- Cytochrome P-450 Enzyme System
- Dementia
- Female
- Humans
- Male
- Middle Aged
- Perphenazine
- Pharmaceutical Preparations
- Phenotype
- Psychiatric Status Rating Scales