Article
Application of microarray technology in psychotropic drug trials.
Journal of psychopharmacology (Oxford, England) - 1 Jul 2006
Murphy Greer M
Abstract excerpt
Microarrays can be manufactured to detect hundreds of thousands of polymorphisms in DNA from patients in psychotropic drug trials. Some of these polymorphisms may be useful as pharmacogenetic predictors of treatment outcomes. We tested a microarray designed to detect common polymorphisms in the CYP2D6 gene that encodes debrisoquine hydroxylase (DH). DH is involved in the hepatic metabolism of many psychotropics....
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